Dual pH‐ and thermal‐responsive nanocomposite hydrogels for controllable delivery of hydrophobic drug baicalein

Hydrogels have been widely used as mild biomaterials due to their bio‐affinity, high drug loading capability and controllable release profiles. However, hydrogel‐based carriers are greatly limited for the delivery of hydrophobic payloads due to the lack of hydrophobic binding sites. Herein, nano‐liposome micelles were embedded in semi‐interpenetrating poly[(N‐isopropylacrylamide)‐co‐chitosan] (PNIPAAm‐co‐CS) and poly[(N‐isopropylacrylamide)‐co‐(sodium alginate)] (PNIPAAm‐co‐SA) hydrogels which were responsive to both temperature and pH, thereby establishing tunable nanocomposite hydrogel delivery systems. Nano‐micelles formed via the self‐assembly of phospholipid could serve as the link between hydrophobic drug and hydrophilic hydrogel due to their special amphiphilic structure. The results of transmission and scanning electron microscopies and infrared spectroscopy showed that the porous hydrogels were successfully fabricated and the liposomes encapsulated with baicalein could be well contained in the network. In addition, the experimental results of response release in vitro revealed that the smart hydrogels showed different degree of sensitiveness under different pH and temperature stimuli. The results of the study demonstrate that combining PNIPAAm‐co‐SA and PNIPAAm‐co‐CS hydrogels with liposomes encapsulated with hydrophobic drugs is a feasible method for hydrophobic drug delivery and have potential application prospects in the medical field. © 2018 Society of Chemical Industry     

管桁架焊缝质量检测机器人结构与越障稳定性研究

管桁架焊缝质量检测机器人是一种在高空管桁架上采集焊缝信息,并对焊缝质量进行适时检测的机器人,它的越障稳定性是其安全可靠工作的关键.设计了一款能在管桁架上行走、越障,且适应管径变化的机器人系统;分别对沿竖直钢管爬升、周向旋转和越障状态下的驱动轮进行受力分析,初选了关键动作驱动电机参数;利用ADAMS平台进行翻转机构的运动学仿真,发现翻转角速度可影响机器人的工作效率和稳定性,以工作损失效能最小为目标优化翻转角速度,通过数据拟合和多次迭代求得最优翻转角速度;开展了样机稳定性试验,以测量不同翻转角速度下机器人的滑移量.分析和试验结果表明:翻转角速度为0.445 rad/s时,工作损失效能最小,且越障稳定性好;翻转角速度达0.785 rad/s时,出现滑落现象;样机稳定性试验与运动学仿真结果一致.     

Real-time molecular characterization of air pollutants in a Hong Kong residence: Implication of indoor source emissions and heterogeneous chemistry

Due to the high health risks associated with indoor air pollutants and long-term exposure, indoor air quality has received increasing attention. In this study, we put emphasis on the molecular composition, source emissions, and chemical aging of air pollutants in a residence with designed activities mimicking ordinary Hong Kong homes. More than 150 air pollutants were detected at molecular level, 87 of which were quantified at a time resolution of not less than 1 hour. The indoor-to-outdoor ratios were higher than 1 for most of the primary air pollutants, due to emissions of indoor activities and indoor backgrounds (especially for aldehydes). In contrast, many secondary air pollutants exhibited higher concentrations in outdoor air. Painting ranked first in aldehyde emissions, which also caused great enhancement of aromatics. Incense burning had the highest emissions of particle-phase organics, with vanillic acid and syringic acid as markers. The other noteworthy fingerprints enabled by online measurements included linoleic acid, cholesterol, and oleic acid for cooking, 2,5-dimethylfuran, stigmasterol, iso-/anteiso-alkanes, and fructose isomers for smoking, C₂₈-C₃₄ even n-alkanes for candle burning, and monoterpenes for the use of air freshener, cleaning agents, and camphor oil. We showed clear evidence of chemical aging of cooking emissions, giving a hint of indoor heterogeneous chemistry. This study highlights the value of organic molecules measured at high time resolutions in enhancing our knowledge on indoor air quality.     

Indoor solid fuel use for heating and cooking with blood pressure and hypertension: A cross-sectional study among middle-aged and older adults in China

A cross-sectional study was conducted to investigate the impact of solid fuel use for heating and cooking on blood pressure (BP) and hypertension, using data from the China Health and Retirement Longitudinal Study (CHARLS). The primary fuels used for indoor heating and cooking were collected by questionnaires, respectively. Hypertension was defined based on self-report of physician's diagnosis, and/or measured BP, and/or anti-hypertensive medication use. Multivariate logistic regression models were constructed to assess the associations. Among 10 450 eligible participants, 68.2% and 57.2% used indoor solid fuel for heating and cooking, respectively. Compared with none/clean fuel users, solid fuel for heating was associated with elevated BP (adjusted β: 2.02, 95% CI: 1.04–3.01 for systolic BP; adjusted β: 1.36, 95% CI: 0.78–1.94 for diastolic BP) and increased risk of hypertension (adjusted odds ratio: 1.15, 95% CI: 1.03–1.29). The impact of indoor solid fuel for heating on BP was more evident in rural and north residents, and hypertensive patients. We did not detect any significant associations between solid fuel use for cooking and BP/hypertension. Indoor solid fuel use is prevalent in China, especially in the rural areas. Its negative impact on BP suggested that modernization of household fuel use may help to reduce the burden of hypertension in China.     

Evaluation of moisture reduction in aggregate base by wicking geotextile using soil column tests

This study investigated the distance effect on water reduction by the wicking geotextile in a base course experimentally using three sets of soil column tests. In each set of tests, two soil columns were constructed by compacting well-graded aggregate over a non-wicking woven geotextile and a wicking geotextile. A portion of the geotextile specimen was extended outside of the soil column for evaporation. The changes of the water contents in the soil column were monitored by volumetric water content sensors installed at various depths. The experimental results indicate the capillary drainage by the wicking geotextile effectively reduced water content within the soil column up to a distance from the wicking geotextile (i.e., approximately 200 mm for this specific aggregate with 10% fines). The test results also show that the wicking geotextile could reduce more water content of the aggregate below its optimum water content at a faster rate than the non-wicking geotextile.     

脉冲电压下电力电子装备绝缘电荷特性研究综述

电力电子装备长期处于高频、陡脉冲电压的运行工况下,其绝缘系统易发生早期失效,可能会威胁电力系统运行的安全性和可靠性.因此,探究脉冲电压下绝缘劣化机理对保障电力系统安全稳定运行具有重要意义.该文综合国内外研究现状,介绍了几种常见电力电子装备及其运行工况,通过对绝缘体击穿与沿面闪络影响机理的论述,揭示了电荷行为对绝缘劣化的重要作用,阐述了脉冲电压参数对电荷特性影响的研究进展,并对目前研究存在的不足进行了总结与探讨.未来应提升脉冲电压下电荷测试技术,明确脉冲边沿时刻电荷动态特性,以阐明绝缘劣化机理.这些研究成果将为脉冲电压下电力电子装备绝缘材料和电力系统的优化设计提供参考和理论指导.     

Advances in the in vitro digestion and fermentation of polysaccharides

In vitro digestion models are widely used to study the structural changes, digestion and release of food components under simulated gastrointestinal conditions. As compared to the in vivo digestion tests, the in vitro digestion reflects the digestion and utilisation of food after ingestion and has the advantages of being time consuming, inexpensive, reproducible and free from moral and ethical restrictions. This study reviewed the current research studies on the in vitro simulated digestion of polysaccharides conducted in the last 5 years and focused on the oral, gastric and intestinal digestion models, with the aim of providing a basis for the further testing of changes in the content, structure and active ingredients of polysaccharides before and after digestion.     

Pore-scale study of effects of different Pt loading reduction schemes on reactive transport processes in catalyst layers of proton exchange membrane fuel cells

Reducing the Platinum (Pt) loading while maintaining the performance is highly desired for promoting the commercial use of proton exchange membrane fuel cells (PEMFCs). Different methods have been adopted to fabricate catalyst layers (CLs) with low Pt loading, including utilizing lower Pt/C catalysts (MA), mixing high Pt/C catalysts with bare carbon black particles (MB), and reducing CL thickness while maintaining high Pt/C ratio (MC). In this study, self-developed pore-scale model is adopted to investigate the performance of the three Pt reduction methods. It is found that MA shows the best performance while MB shows the worst. Then, effects of Pt dispersion are further explored. The results show that denser Pt sites will result in higher local oxygen flux and thus higher local transport resistance. Therefore, MA method, which shows the better Pt dispersion, leads to improved performance. Third, CLs with quasi-realistic structures are investigated. Higher tortuosity resulting from the random pores produces higher bulk resistance along the thickness direction, while MA still exhibits the best performance. Finally, improved CL structures are investigated by designing perforated CL structures. It is found that adding perforations can significantly reduce the bulk transport resistance and can improve the CL performance. It is demonstrated that CL structure plays important roles on performance, and there are still huge potentials to further improve CL performance by increasing Pt dispersion and optimizing CL structures.     

Techno-economic analysis of hydrogen energy for renewable energy power smoothing

With the increasing proportion of renewable energy (mainly wind power and photovoltaic) connected to the grid, the fluctuation of renewable energy power brings great challenges to the safe and reliable operation of power grid. As a clean, low-carbon secondary energy, hydrogen energy is applied in renewable energy (mainly wind power and photovoltaic) grid-connected power smoothing, which opens up a new way of coupling hydrogen storage energy with renewable energy. This paper focuses on the optimization of capacity of electrolyzers and fuel cells and the analysis of system economy in the process of power output smoothing of wind/photovoltaic coupled hydrogen energy grid-connected system. Based on the complementary characteristics of particle swarm optimization (PSO) and chemical reaction optimization algorithm (CROA), a particle swarm optimization-chemical reaction optimization algorithm (PSO-CROA) are proposed. Aiming at maximizing system profit, the capacity of electrolyzers and fuel cells are constrained by wind power fluctuation, and considering environmental benefits, government subsidies and time value of funds, the objective function and its constraints are established. According to the simulation analysis, by comparing the calculated results with PSO and CROA, it shows that PSO-CROA effectively evaluates the economy of the system, and optimizes the optimal capacity of the electrolyzers and fuel cells. The conclusion of this paper is of great significance for the application of hydrogen energy storage in the evaluation of power smoothness and economy of renewable energy grid connection and the calculation of economic allocation of hydrogen energy storage capacity.